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He called it Bio-Fusion, the technique of manipulating genetic material to splice with mechanical attachments.
~ Owen Routh on Bio-Fusion

Bio-Fusion is the process of splicing DNA with mechanical attachments.

History[]

Originally starting off as an experimental attempt to revive Thomas back from the dead, Bio-Fusion was used multiple times on multiple people to fuse them with various trains as a way of tourism for Sodor. But these Bio-Fusion experiments didn't have as much work put into them as Thomas did. Therefore a lot of the bio-fused engines had various problems, with most of them either becoming too sick to work or dying during their operation or on their first test run as a result. After Thomas had found out he was never Bio-Fused, a government enquiry was launched involving the events on Sodor, with Bio-Fusion being banned the following year. However, China still uses Bio-Fusion as a compulsory punishment for political criminals. Bio-Fusion was also banned in Europe, though the trains were still required to run.

However, despite the ban, the government continued Bio-Fusion through HiT Logistics until 2015.

How does Bio-Fusion work in real life or the Shed 17 universe?[]

Splicing DNA with mechanical attachments is a way of manipulating the process of removing and joining segments of RNA, which are transcribed from DNA, to produce functional messenger RNA (mRNA) that can be translated into proteins. This process is normally performed by a complex molecular machine called the spliceosome, which consists of proteins and RNA molecules. However, some researchers have explored the possibility of using mechanical devices, such as magnetic tweezers or DNA origami, to apply forces or induce conformational changes to the RNA molecules, and thereby alter the splicing efficiency and outcome. This could have potential applications in biotechnology and medicine, such as modulating gene expression or creating hybrid organisms. However, there are also many challenges and limitations to this approach, such as the specificity, stability, and delivery of the devices, as well as the ethical and safety implications of modifying gene expression. Therefore, more research is needed to understand the mechanisms and consequences of DNA splicing with mechanical attachments. *Not all of this info explained is 100% accurate and has never been done before.* This is in a hypothetical event explained by GPT-4.

Subjects[]

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